Biotage

06/08/2026

Need a simpler way to remove residual water before concentration? We’ve got you covered.

Our Applications Chemist, Deanna Borisko, explains how with in-line extract drying on the Biotage® PrepXpert-8 you can:

🧪 Meet SVOC method requirements by effectively removing water prior to analysis
🧪 Easily set up in-line drying with sodium sulfate using simple, built-in method steps
🧪Reduce labor and time—no baking Na₂SO₄, fewer transfers, and less solvent use.

Watch video: https://hubs.ly/Q04mN5Bq0

Subscribe to our YouTube channel for more sample preparation tips, workflows, and application insights.

Need a simpler way to remove residual water before concentration? W...

04/08/2026

Tissue analysis is essential for understanding the distribution, metabolism, and potential toxicity of therapeutic oligonucleotides. However, extracting oligonucleotides from complex matrices such as liver remains a significant analytical challenge. 👩‍🔬

Proteins, lipids, endogenous nucleic acids, nucleases, and other matrix components can reduce extraction efficiency and compromise the reproducibility of LC-MS analysis. Effective sample preparation is therefore critical to isolate the analyte, minimize matrix interferences, and achieve reliable quantitation.

In this application note, we demonstrate a workflow using Biotage® Oligo SPE for the extraction of mipomersen from liver tissue, achieving recoveries of ≥70% with reliable quantitation.

Read the application note to explore how the method could be adapted to your own oligonucleotide workflows: https://hubs.ly/Q04n1GN40

28/07/2026

One of the biggest challenges in large-scale flash chromatography isn't just developing a method, it's scaling it consistently. 📈

Changing chromatography platforms or packing your own columns during scale-up can introduce unnecessary variability and extra work, making it harder to achieve consistent results.

Biotage configurable scale-up columns help simplify the transition from development through pilot to manufacturing. The prepacked columns scale seamlessly between our platforms to help reduce variability, save time, and support more reproducible purification.

Learn more about configurable scale-up columns here: https://hubs.ly/Q04mWJw90

22/07/2026

"With TurboVap®, what previously took more than two hours can now be completed in under 20 minutes."

As PFAS testing demands continue to grow, laboratories are under increasing pressure to improve throughput without compromising quality. For Ms. Megumi Monden's team, accelerating a key sample preparation step helped eliminate a major workflow bottleneck, enabling same-day completion of analyses that previously risked carrying over into the next day.

Read how the team optimized their PFAS sample preparation workflow: https://hubs.ly/Q04mCMkF0

20/07/2026

Are your peptides degrading too easily? Associate Professor Caroline Proulx joined us for a webinar exploring how azapeptides and non-natural amino acids can be utilized to engineer more stable molecules by highlighting innovations that enhance peptide stability and facilitate automated synthesis.

Access the on-demand recording now: https://hubs.ly/Q04gpkX60

07/07/2026

As peptide synthesis workflows evolve, the question is no longer only whether a solvent works, but whether it works efficiently and sustainably. In this blog, Biotage evaluates binary solvent mixtures in automated SPPS and shows that method optimization can reduce solvent use while maintaining strong performance. It is a useful reminder that greener chemistry can still be compatible with robust automation.

Discover which binary solvent mixtures can support more efficient and sustainable SPPS in the full blog written by our Application Scientist, Symone Stribling: https://hubs.ly/Q04lxtcW0

02/07/2026

When running reversed-phase chromatography, do you ever notice peak splitting or poor resolution? 🧪

In this quick tip, we show how adding a mobile phase modifier to your solvent system can improve separation and resolution.

Subscribe to our YouTube channel for more sample preparation tips, workflows and application insights.

When running reverse-phase chromatography, do you ever notice peak ...

30/06/2026

Antibiotics are increasingly being detected in aquatic environments, creating new challenges for environmental monitoring and water quality analysis.
Join us and Separation Science for a webinar on July 8, exploring an automated SPE approach for the extraction and enrichment of multiple antibiotic classes from water samples using the Biotage® PrepXpert-8.

In this webinar, you'll learn:
💧 Practical strategies for automated SPE method development
💧 How automation can help improve reproducibility and reduce operator variability
💧 Key considerations for developing methods for different antibiotics, including fluoroquinolones, tetracyclines, sulfonamides, and macrolides

Save your spot:
https://hubs.ly/Q04lw_B50

18/06/2026

Are your peptides degrading too easily? Associate Professor Caroline Proulx joined us for a webinar exploring how azapeptides and non-natural amino acids can be utilized to engineer more stable molecules by highlighting innovations that enhance peptide stability and facilitate automated synthesis.

Access the on-demand recording now: https://hubs.ly/Q04gpsXQ0

09/06/2026

Last chance to see automated flash chromatography in action!

Join our live Biotage® Selekt demo this Thursday, to watch a full purification run, explore practical solutions, and learn how automated setup and method creation can significantly reduce manual prep time while improving reproducibility.

We will be hosting two sessions, join us at your convenience:

Session 1 at 9 AM EDT / 2 PM BST / 3 PM CEST: https://hubs.ly/Q04kfVdt0

Session 2 at 11 AM PST / 2 PM EDT: https://hubs.ly/Q04kfPCH0

Can't attend live? Register anyway and we'll send you the recording.