02/06/2026
🔬New HemaScope Case!
This month, our case is AML-M4Eo (Acute Myelomonocytic Leukemia with Eosinophilia) is a distinct subtype of Acute Myeloid Leukemia characterized by both granulocytic and monocytic differentiation, along with abnormal eosinophils in the bone marrow.
Key diagnostic findings may include increased blast cells, MPO positivity, non-specific esterase positivity inhibited by sodium fluoride, and the presence of abnormal eosinophilic precursors. These combined morphological and cytochemical features support the classification of AML-M4Eo within the FAB system.
Cases such as this highlight the important role of CBC and differential analysis as an initial step in identifying hematological abnormalities. Advanced hematology analyzers support laboratories by providing reliable CBC and differential results, abnormal cell flags, and analytical information that can assist in determining when further smear review and diagnostic investigation are required.
In current WHO/ICC terminology, findings suggestive of AML-M4Eo should be followed by cytogenetic or molecular confirmation for inv(16)/t(16;16) or CBFB::MYH11.
Accurate hematology analysis remains essential for supporting early clinical suspicion and guiding appropriate follow-up investigations.
Stay tuned for our next educational cases!
