10/08/2026
⭐ 5× Higher Adhesion For Buccal Peptide Delivery Using infinityPV Slot-die Coater ⭐
Imagine taking a peptide drug without swallowing it or injecting it. Instead, a small film could be placed against the inside of the cheek, where it sticks to the moist tissue and gradually releases the drug.
This is the approach investigated in a new study from researchers at the DTU - Technical University of Denmark, Novo Nordisk, Universidade de Aveiro, and collaborating institutions.
The team developed a thin, two-layer film containing a GLP-1 receptor agonist, a type of peptide drug, together with a substance that helps the peptide pass through the tissue. One layer contains the drug and is designed to stick to the cheek, while the second layer acts as a backing layer to support the film and direct the release towards the tissue.
The researchers used slot-die coating to manufacture the films. By changing the chemical structure of the pullulan-based adhesive, the researchers changed the film's adhesion, swelling, cohesion, and release behavior.
⭐ Key Highlights ⭐
• 5× higher adhesion: The 3% MD formulation reached 102.6 ± 14.2 J/m², approximately five times the adhesion reported for conventional buccal films.
• More sustained release: 75.5 ± 14.6% of GLP-1-RA was released after 30 minutes from the 3% MD film, compared with 99.2 ± 1.6% from the 0% MD film.
• Two distinct layers: Slot-die coating was used to fabricate an active mucoadhesive layer and a cellulose-based backing layer.
👉 Learn more: https://lnkd.in/e6y8w8yz
👉 Thin thin drug delivery: https://lnkd.in/eVMHEywC
👉 Slot-die Coater: https://lnkd.in/dvNqCczf
Authors:
• Margarida Sacramento
• Nazanin Zanjanizadeh Ezazi
• Eleftheria Pantazoglou
• Philip Mark Lund
• Marco van de Weert
• Zhongyang Zhang
• Rui Vitorino
• Floriane Bahuon
• Ragna Berthelsen
• Stephen Buckley
• Gavrielle Untracht
• Peter Eskil Andersen
• David Brayden
• Ana Silva
• Joao Rodrigues
• João F. Mano
• Line Hagner Nielsen